Photonics based Telemedicine Technologies toward Smart Global Health Systems
Sep 21, 2010
from 02:00 PM to 03:00 PM
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Assistant Professor Aydogan Ozcan
UCLA Electrical Engineering
Tuesday, September 21, 2010 at 2:00PM
54-134 Engineering IV Building
Today there are more than 4 billion cell-phone users in the world, and the majority of these cellphones are being used in the developing parts of the world. This massive volume of wireless phone communication brings an enormous cost-reduction to cellphones despite their sophisticated hardware and software capabilities. Quite importantly, most of these existing cellphones are also already equipped with advanced digital imaging and sensing platforms that can be utilized for various health monitoring applications. This impressive advancement is one of the central building blocks of the emerging fields of "Telemedicine" and "Wireless Health". The success of these fields will surely increase the quality of health care and reduce the insurance costs in developed countries like the United States, however, their most important and immediate impact will be to provide breakthrough technological solutions to various Global Health Problems including infectious diseases such as HIV, TB or malaria. Specifically, utilizing this advanced state of the art of the cell phone technology towards point-of-care diagnostics and/or microscopic imaging applications can offer numerous opportunities to improve health care especially in the developing world where medical facilities and infrastructure are extremely limited or even do not exist.
Centered on this vision, in this talk I will introduce fundamentally new imaging and detection architectures that can compensate in the digital domain for the lack of complexity of optical components by use of novel theories and numerical algorithms to address the immediate needs and requirements of Telemedicine for Global Health Problems. Specifically, I will present an on-chip cytometry and microscopy platform that utilizes cost-effective and compact components to enable digital recognition and 3D microscopic imaging of cells with sub-cellular resolution over a large field of view without the need for any lenses, bulky optical components or coherent sources such as lasers. This incoherent holographic imaging and diagnostic modality has orders of magnitude improved light collection efficiency and is robust to misalignments which eliminates potential imaging artifacts or the need for realignment, making it highly suitable for field use. Applications of this lensfree on-chip microscopy platform to high-throughput imaging and automated counting of whole blood cells, monitoring of HIV+ patients (through CD4 and CD8 T cell counting) and detection of waterborne parasites towards rapid screening of water quality will also be demonstrated. Further, I will discuss lensfree implementations of various other computational imaging modalities on the same on-chip platform such as pixel super-resolution imaging and lensless differential interference contrast (DIC) microscopy. Finally, I will demonstrate lensfree on-chip imaging of fluorescently labeled cells over an ultra wide field of view of >8 cm2, which is especially important for rare cell analysis (e.g., detection of circulating tumor cells), as well as for high-throughput screening of DNA/protein micro-arrays.
Dr. Aydogan Ozcan received his Ph.D. degree at Stanford University Electrical Engineering Department in 2005. After a short post-doctoral fellowship at Stanford University, he is appointed as a Research Faculty Member at Harvard Medical School, Wellman Center for Photomedicine in 2006. Dr. Ozcan joined UCLA in the summer of 2007 as an Assistant Professor, where he is currently leading the Bio- and Nano-Photonics Laboratory at the Electrical Engineering Department.
Dr. Ozcan holds 17 issued patents and another 8 pending patent applications for his inventions in nanoscopy, wide-field imaging, lensless imaging, nonlinear optics, fiber optics, and optical coherence tomography. Dr. Ozcan is also the author of one book and the co-author of more than 120 peer reviewed research articles in major scientific journals and conferences. In addition, Dr. Ozcan is the founder and a member of the Board of Directors of Holocope LLC, and is a member of the program committee of SPIE Photonics West Conference, SPIE International Symposium on Defense, Security and Sensing, as well as the IEEE Photonics Society Annual Meeting. He also serves as a panelist and a reviewer for National Science Foundation, NIH and for Harvard-MIT Innovative Technology for Medicine Program. Prof. Ozcan also served as the General co-Chair of 2010 IEEE Winter Topical Meeting on Advanced Imaging in BioPhotonics.
Prof. Ozcan received the 2010 NSF CAREER Award, the 2009 NIH Director's New Innovator Award, the 2009 Office of Naval Research (ONR) Young Investigator Award, the 2009 IEEE Photonics Society (LEOS) Young Investigator Award and the MIT's Technology Review TR35 Award for his seminal contributions to near-field and on-chip imaging, and telemedicine based diagnostics. Prof. Ozcan is also the recipient of the 2010 National Geographic Emerging Explorer Award, the 2010 Bill & Melinda Gates Foundation Grand Challenges Award, the 2010 Popular Mechanics Breakthrough Award, the 2010 Netexplorateur Award given by the Netexplorateur Observatory & Forum in France, and the 2009 Wireless Innovation Award organized by the Vodafone Americas Foundation as well as the 2008 Okawa Foundation Award, given by the Okawa Foundation in Japan.Dr. Ozcan is a Senior Member of IEEE, and a member of LEOS, EMBS, OSA, SPIE and BMES.