Advances in Biomedical Imaging at UCLA
May 03, 2013
from 11:00 AM to 12:30 PM
|Where||Engr. IV Bldg., Shannon Room 54-134|
|Contact Name||Prof. Oscar Stafsudd|
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Bio-Engineering Department, UCLA
Medical imaging has been the subject of much interest in the THz community recently due to promising results obtained in ex vivo and in vivo tissues. The dielectric properties of water and other tissue constituents at THz frequencies are unique and significant contrast can be generated with THz illumination that is unavailable to currently accepted medical imaging modalities. This talk presents a pulsed, reflective THz imaging system operating at ~525 GHz center frequency with ~ 125 GHz of bandwidth and developed specifically for in vivo medical imaging applications. Following system architecture discussions two promising THz medical imaging applications are presented; burns wound assessment and corneal hydration sensing. For burns, THz images are presented of partial thickness and full thickness burns obtained in rat models in vivo over a 72 hour period. These results clearly show the evolution of wound edema and may provide burn surgeons with tools for early severity assessment. For cornea, images are presented of corneal hydration obtained in vivo from 78% - 81 % hydration by volume. The data indicates a hydration sensitivity of ~ 0.3% by volume and may offer ophthalmologists a diagnostic for the early detection of corneal graft rejection, Fuchs' dystrophy, and other diseases/pathologies associated with corneal health.
Additional biomedical projects including lifetime fluorescence imaging for tumor identification and laser generated shockwaves for failed wound treatment will be highlighted.
Zach Taylor received the B.S. degree in electrical engineering from UCLA in 2004 and the M.S. and Ph.D. degrees in electrical engineering from UCSB in 2006 and 2009 respectively working with Professor Elliott Brown. He is currently the engineering director of the Bio-photonics Laboratory in the Dept. of Bioengineering at UCLA and a medical engineering investigator at Center for Advanced Surgical and Interventional Technology (CASIT) in the UCLA Dept. of Surgery and works in collaboration with Professor Warren Grundfest on a number of diagnostic imaging projects.
Dr. Taylor was successful in obtaining the first NIH R01 grant ever funded for THz research and the first NIH R21 funded for THz burn imaging. He is currently conducting imaging research in collaboration with the departments of Electrical Engineering, Pathology, General surgery, and Ophthalmology at UCLA. His research interests include biomedical optics, imaging system design, and novel contrast generation mechanisms.