Paper-Based Lateral Flow Biosensing Platforms for High-Performance Point-of-Care Testing

Speaker: Dr. Gyeo-Re Han
Affiliation: Gwangju Institute of Science and Technology (GIST)

Via Zoom only:  https://ucla.zoom.us/j/98682901619

 

Abstract:  Paper-based lateral flow assays (LFAs) are among the most widely used biosensing platform for point-of-care testing. However, the conventional colloidal gold label of LFAs shows low analytical capacity. Alternatively, the use of enzyme/chemical reaction-based signal amplification with structural modifications has enhanced the analytical capacity. However, it requires multiple user interventions as a trade-off, increasing complexity, test imprecision, and time. In the present talk, we will introduce our efforts to develop highly sensitive, automated, universal, and manufacturable point-of-care biosensing platforms overcoming the drawbacks above. The content specifically includes; (i) nanomaterial-based bioconjugation for high-sensitivity immunoassay, (ii) advanced paper-based diagnostic platforms for automated reactions in LFAs, and (iii) the application of these for the high-performance testing of cardiac biomarker, troponin I. We hope that these works will serve as a useful diagnostic countermeasure when dealing with challenging biomarkers requiring quality testing in point-of-care situations.

 

   References

  • Han, G.-R.; Ki, H.; Kim, M.-G. Automated, Universal, and Mass-Producible Paper-Based Lateral Flow Biosensing Platform for High-Performance Point-of-Care Testing. ACS Appl. Mater. Interfaces2020, 12, 1885–1894.
  • Han, G.-R.; Koo, H. J; Ki, H.; Kim, M.-G. Paper/Soluble Polymer Hybrid-Based Lateral Flow Biosensing Platform for High-Performance Point-of-Care Testing. ACS Appl. Mater. Interfaces2020, 12, 34564–34575.

 

 

Biography:   Gyeo-Re Han is a postdoctoral researcher in the Department of Chemistry at Gwangju Institute of Science and Technology (GIST, Republic of Korea), where he received his Ph.D. degree under the guidance of Prof. Min-Gon Kim.  Prior to GIST, he obtained his B.S. and M.S. in Biomedical Engineering from Gachon University, Republic of Korea.  From 2021, he serves as a Topic Editorial Board Member of Micromachines (MDPI).  His research interests lie in the area of biosensors, high-performance point-of-care testing, paper-based diagnostics, mobile health for global health, and micro/nanotechnology.

 

For more information, contact Prof. Aydogan Ozcan (ozcan@g.ucla.edu)

Date/Time:
Date(s) - Jan 20, 2021
4:00 pm - 5:30 pm

Location:
Via Zoom Only
No location, Los Angeles
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