Development of the Next Generation of Biophotonic/Photonic Imaging Systems

Speaker: Prof. Tomasz S. Tkaczyk
Affiliation: Rice University

Abstract:  Photonic technologies bridge many fields and enable applications spanning, for example, from biological and biomedical diagnostics to remote sensing and imaging. The new optical design and fabrication methods that I have developed in my lab provide freedom of optical design and allow new system functionalities. This presentation focuses on demonstrating these capabilities and future opportunities including examples of integrated diagnostic optics as well as multidimensional snapshot imaging systems. These distinct and different groups both depend on enabling manufacturing/design technologies. In the beginning I will present a case study of multimodal biological imaging and diagnostics. Presented solutions will provide morphology and spectrum, two important characteristics that can yield high specificity and sensitivity. Two main groups of devices will be discussed: (1) miniature-integrated imaging microscopes (endo-microscopes) to provide morphological content and (2) multi and hyperspectral high speed systems to obtain bio-chemical signatures. Practical aspects of multi-modal system integration, fabrication and data processing will be discussed together with the design considerations to balance field of view and resolution of individual sub-systems. Number of imaging results will be presented including (for morphological assessment): contact imaging, confocal, structure illumination, and multi-photon imaging and (in area of spectral detection) narrow band imaging (NBI), image mapping spectrometry IMS, and array snapshot systems. Application examples will include cancer diagnostics: for oral, cervical and esophageal adenocarcinoma. After discussing multi-modal imaging case, I will demonstrate versatility of presented approaches and their impact on other fields and their implementations in areas of point of care (POC), retinal functional imaging, brain imaging, remote sensing etc. The presentation will be closed by discussing future opportunities and their potential impact on bio-photonic and photonic detection. Specifically, I will talk about early efforts of allowing photonic solutions with additive manufacturing methods.

Biography:  Tomasz S. Tkaczyk received his MS and PhD degrees from the Institute of Micromechanics and Photonics, Warsaw University of Technology. Currently, he is an Associate Professor of Bioengineering and Electrical and Computer Engineering at Rice University. He joined Rice University in 2007 after his research at the University of Arizona. His work is in instrumentation including spectroscopy, integrated optics, microscopy, diagnostic and point of care systems. He has published 75+ per-reviewed communications. Dr. Tkaczyk is a fellow of OSA and SPIE, and recipient of number of professional awards including Paul F. Forman Engineering Excellence Award (OSA) and Becton Dickinson Professional Achievement Award (AAMI).

For more information, contact Prof. Aydogan Ozcan ()

Date/Time:
Date(s) - Mar 25, 2019
11:00 am - 12:15 pm

Location:
E-IV Tesla Room #53-125
420 Westwood Plaza - 5th Flr., Los Angeles CA 90095