Dose-volume Requirements Modeling for Radiotherapy Optimization

Speaker: Yuriy Zinchenko
Affiliation: University of Calgary


Radiation therapy is an important modality in cancer treatment. To find a good treatment plan, optimization models and methods are typically used, while dose-volume requirements play an important role in plan’s quality evaluation.  We compare four different optimization approaches to incorporate the so-called dose-volume constraints into the fluence map optimization problem for intensity modulated radiotherapy.  Namely, we investigate (1) conventional Mixed Integer Programming (MIP) approach; (2) Linear Programming (LP) approach to partial volume constraints; (3) Constrained Convex Moment (CCM) approach; and (4) Unconstrained Convex Moment Penalty (UCMP) approach. The performance of the respective optimization models is assessed using anonymized data corresponding to eight previously treated prostate cancer patients. Several benchmarks are compared, with the goal to evaluate the relative effectiveness of each method to quickly generate a good initial plan, with emphasis on conformity to DVH-type constraints, suitable for further, possibly manual, improvement.


Dr. Yuriy Zinchenko received his PhD from Cornell University on 2005 under supervision of Prof. James Renegar.   From 2005 to 2008, he held a PDF position at the Advanced Optimization Lab at McMaster University, working with Prof. Tamas Terlaky and Prof. Antone Deza and spent portion of his fellowship with radiation oncology group at the Princess Margaret Hospital in Toronto. Currently, Yuriy is an Associate Professor of Mathematics & Stat at the University of Calgary.  Dr. Zinchenko’s primary research interest lies in convex optimization, and particularly, the curvature of the central path for interior-point methods and applications. Yuriy’s work on optimal radiotherapy design was recognized by 2008 MITACS Award for Best Novel Use of Mathematics in Technology Transfer, and in 2012-2015, he served as one of the PIs for PIMS Collaborative Research Group grant on optimization.

For more information, contact Prof. Lieven Vandenberghe ()

Date(s) - Apr 28, 2017
11:00 am - 12:30 pm

E-IV Faraday Room #67-124
420 Westwood Plaza - 6th Flr., Los Angeles CA 90095